{"id":748,"date":"2025-08-26T10:34:17","date_gmt":"2025-08-26T01:34:17","guid":{"rendered":"https:\/\/www.globalblooming.com\/en\/?page_id=748"},"modified":"2025-09-08T11:09:26","modified_gmt":"2025-09-08T02:09:26","slug":"bnct-project-1102-2","status":"publish","type":"page","link":"https:\/\/www.bloomx3.com\/en\/bnct-project-1102-2\/","title":{"rendered":"BNCT Project 1102"},"content":{"rendered":"\n<p>The Global Blooming (Currently, <strong>Bloom X\u00b3<\/strong>) is advancing <strong>Project 1102<\/strong> centered on BNCT (Boron Neutron Capture Therapy). Led by a drug-discovery expert and a world-class team, we are building a drug \u00d7 platform that enables highly selective retention of boron carriers in target cells (including cancer cells). Our aim is practical implementation focused on refractory cancers, rejuvenation, and regenerative medicine.<\/p>\n\n\n\n<p><strong>News:<\/strong> On <strong>August 25, 2025<\/strong>, Project 1102 was publicly announced as <strong>selected for JETRO\u2019s <a href=\"https:\/\/www.jetro.go.jp\/en\/news\/announcement\/2025\/dba596da61a037b7.html\">\u201cSubsidy for Projects to Stimulate Direct Investment in Japan\u201d<\/a><\/strong>. This support will accelerate our R&amp;D and international collaboration.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"973\" height=\"246\" src=\"https:\/\/www.bloomx3.com\/en\/wp-content\/uploads\/sites\/2\/2025\/08\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2025-08-26-13.44.58.png\" alt=\"\" class=\"wp-image-751\" srcset=\"https:\/\/www.bloomx3.com\/en\/wp-content\/uploads\/sites\/2\/2025\/08\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2025-08-26-13.44.58.png 973w, https:\/\/www.bloomx3.com\/en\/wp-content\/uploads\/sites\/2\/2025\/08\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2025-08-26-13.44.58-300x76.png 300w, https:\/\/www.bloomx3.com\/en\/wp-content\/uploads\/sites\/2\/2025\/08\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2025-08-26-13.44.58-768x194.png 768w\" sizes=\"(max-width: 973px) 100vw, 973px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">Why BNCT<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Simple:<\/strong> Physically destroys complex therapeutic targets whose organ- and intracellular mechanisms are difficult to modulate pharmacologically.<\/li>\n\n\n\n<li><strong>Combination therapy:<\/strong> Flexible options to combine with other therapeutics.<\/li>\n\n\n\n<li><strong>Selectivity:<\/strong> Neutron irradiation targets cells that have accumulated boron isotopes, aiming to destroy cancer cells while sparing others.<\/li>\n\n\n\n<li><strong>Lower patient burden:<\/strong> Provides options where surgery or standard care is limited.<\/li>\n\n\n\n<li><strong>Unmet needs:<\/strong> High demand to balance efficacy and quality of life in hard-to-treat areas such as head and neck cancers.<\/li>\n\n\n\n<li><strong>Minimizing animal experiments:<\/strong> A development scheme that supports reduction of animal use\u2014an increasingly prioritized regulatory perspective\u2014via direct physical mechanisms and verifiable testing.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Our Approach (Drug \u00d7 Platform)<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Carrier design:<\/strong> Integrated optimization of specificity, intracellular retention, and safety for target cells.<\/li>\n\n\n\n<li><strong>Delivery optimization:<\/strong> Multilayer optimization informed by the tumor microenvironment and cellular kinetics.<\/li>\n\n\n\n<li><strong>Protocol integration:<\/strong> <strong>Clinic-minded <\/strong>design aligned with dosing and irradiation conditions.<\/li>\n\n\n\n<li><strong>Platformization:<\/strong> A cross-functional foundation connecting molecule design, preclinical evaluation, and data governance.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Focus Areas (Specialization &amp; Applications)<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Refractory cancers:<\/strong> Focus on indications where current therapies have limited benefit.<\/li>\n\n\n\n<li><strong>Rejuvenation:<\/strong> Exploration of strategies to modulate age-related target cell populations.<\/li>\n\n\n\n<li><strong>Regenerative medicine:<\/strong> Evaluation of selective control of inhibitory cell groups and potential preconditioning use cases.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Operating Structure<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Lead:<\/strong> The Global Blooming (TGB) \/ Project 1102<\/li>\n\n\n\n<li><strong>Collaboration:<\/strong> National research institutes and universities in Japan, and academia\/biotechs in Europe and the U.S. (in developing)<\/li>\n\n\n\n<li><strong>R&amp;D Stage:<\/strong> <strong>Drug discovery &amp; platform building<\/strong><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Partner Selection<\/h3>\n\n\n\n<p>Project 1102 is not a device-development project. However, co-design and co-implementation with optimal irradiation-system manufacturers is critical for real-world deployment.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Who we work with:<\/strong> Irradiation-system manufacturers, biopharma\/biotech, medical institutions, and universities<\/li>\n\n\n\n<li><strong>Scope:<\/strong> Preclinical validation, implementation-protocol design, and regulatory\/quality readiness as collaborative implementation partners<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Key Differentiation<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Retention-centric drug design:<\/strong> A triad of specificity, persistence, and safety, enhanced by AI-assisted design.<\/li>\n\n\n\n<li><strong>Execution-driven decisions:<\/strong> Rapid, pragmatic validation led by a drug-discovery expert with a world-class team.<\/li>\n\n\n\n<li><strong>Historically grounded insight &amp; empirical reasoning:<\/strong> Practical data interpretation and project execution that avoid the common pitfalls of generative AI.<\/li>\n\n\n\n<li><strong>Platform mindset:<\/strong> Data-driven reproducibility and extensibility from R&amp;D to implementation.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Related Pages<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.bloomx3.com\/en\/business-our-services\/\">Businesses (Overview)<\/a><\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong>Disclaimer:<\/strong> This page is for R&amp;D information and <strong>does not constitute medical advice<\/strong>. Treatment decisions must be made by qualified healthcare professionals.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.bloomx3.com\/en\/contact-us\/\">Contact (Collaboration \/ Implementation \/ Investment)<\/a><\/p>\n\n\n\n\n","protected":false},"excerpt":{"rendered":"<p>The Global Blooming (Currently, Bloom X\u00b3) is advancing Project 1102 centered on BNCT (Boron Neutron Capture Therapy). Led by a drug-discovery expert and a world-class team, we are building a drug \u00d7 platform that enables highly selective retention of boron carriers in target cells (including cancer cells). Our aim is practical implementation focused on refractory [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"swell_btn_cv_data":"","footnotes":""},"class_list":["post-748","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>BNCT Project 1102 - Bloom X\u00b3<\/title>\n<meta name=\"description\" content=\"Project 1102 builds a BNCT drug platform for selective boron retention, focused on refractory cancers, rejuvenation, and regenerative medicine.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.bloomx3.com\/en\/bnct-project-1102-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"BNCT Project 1102 | The Global Blooming\" \/>\n<meta property=\"og:description\" content=\"Selected by JETRO on Aug 25, 2025, Project 1102 advances a BNCT drug platform for selective boron retention\u2014targeting refractory cancers, rejuvenation, and regenerative medicine.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.bloomx3.com\/en\/bnct-project-1102-2\/\" \/>\n<meta property=\"og:site_name\" content=\"Bloom X\u00b3\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-08T02:09:26+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.bloomx3.com\\\/en\\\/bnct-project-1102-2\\\/\",\"url\":\"https:\\\/\\\/www.bloomx3.com\\\/en\\\/bnct-project-1102-2\\\/\",\"name\":\"BNCT Project 1102 - 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